TY - JOUR T1 - The Drug-Drug Interaction Potential of Antiviral Agents for the Treatment of Chronic Hepatitis C Infection JF - Drug Metabolism and Disposition JO - Drug Metab Dispos SP - 1212 LP - 1225 DO - 10.1124/dmd.117.079038 VL - 46 IS - 8 AU - Kimberly L. Garrison AU - Polina German AU - Erik Mogalian AU - Anita Mathias Y1 - 2018/08/01 UR - http://dmd.aspetjournals.org/content/46/8/1212.abstract N2 - Several safe and highly effective direct-acting antiviral (DAA) drugs for chronic hepatitis C virus (HCV) have been developed and greatly increase the number of therapeutic options available to successfully treat HCV infection. However, because treatment regimens contain at least two drugs (e.g., elbasvir and grazoprevir, glecaprevir and pibrentasvir, or sofosbuvir with daclatasvir, simeprevir, ledipasvir, or velpatasvir) and up to five drugs (ombitasvir/paritaprevir/ritonavir plus dasabuvir with or without ribavirin), the potential for drug-drug interactions (DDIs) becomes an important consideration for HCV-infected individuals with comorbidities that require concomitant medications, such as human immunodeficiency virus/HCV coinfection or immunosuppression after liver transplantation. This review details the pharmacokinetics and DDI potential of approved DAAs for the treatment of HCV infection. ER -