PT - JOURNAL ARTICLE AU - Karl-Dimiter Bissig AU - Weiguo Han AU - Mercedes Barzi AU - Nataliia Kovalchuk AU - Liang Ding AU - Xiaoyu Fan AU - Francis P. Pankowicz AU - Qing-Yu Zhang AU - Xinxin Ding TI - P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity AID - 10.1124/dmd.118.083303 DP - 2018 Nov 01 TA - Drug Metabolism and Disposition PG - 1734--1744 VI - 46 IP - 11 4099 - http://dmd.aspetjournals.org/content/46/11/1734.short 4100 - http://dmd.aspetjournals.org/content/46/11/1734.full SO - Drug Metab Dispos2018 Nov 01; 46 AB - Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost-effective and rapid development of new therapies.