RT Journal Article SR Electronic T1 P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity JF Drug Metabolism and Disposition JO Drug Metab Dispos FD American Society for Pharmacology and Experimental Therapeutics SP 1734 OP 1744 DO 10.1124/dmd.118.083303 VO 46 IS 11 A1 Karl-Dimiter Bissig A1 Weiguo Han A1 Mercedes Barzi A1 Nataliia Kovalchuk A1 Liang Ding A1 Xiaoyu Fan A1 Francis P. Pankowicz A1 Qing-Yu Zhang A1 Xinxin Ding YR 2018 UL http://dmd.aspetjournals.org/content/46/11/1734.abstract AB Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost-effective and rapid development of new therapies.