Control | 6 mg/kg Mibefradil | 12 mg/kg Mibefradil | ||||
---|---|---|---|---|---|---|
Observed | Simulated | Observed | Simulated | Observed | Simulated | |
Cmax (ng/ml) | 51.9 | 55.4 | 123 | 153 | 265 | 269 |
Ratio to the control (%) | 100 | 100 | 237 | 276 | 511 | 485 |
AUC0–3 h (ng × h/ml) | 71.8 | 80.1 | 162 | 227 | 391 | 408 |
Ratio to the control (%) | 100 | 100 | 226 | 284 | 545 | 510 |