TABLE 3

Distribution of veliparib and its metabolites in urine and bile from rats and dogs

Data are expressed as percentage of dose. Bold type indicates major excretory metabolites.

Rat (5 mg/kg)Dog (2.5 mg/kg)
UrineBileUrineBile
i.v., 0–24 hp.o., 0–24 hi.v., 0–6 hp.o., 0–6 hi.v., 0–24 hp.o., 0–24 hi.v., 0–6 hp.o., 0–6 h
M1N.D.N.D.N.D.N.D.1.50.7N.D.N.D.
M2N.D.N.D.N.D.N.D.2.21.2N.D.N.D.
M31.61.70.50.311.311.20.50.3
M42.42.50.10.11.50.8MSMS
M5N.D.N.D.0.40.4N.D.N.D.0.20.1
M6N.D.N.D.N.D.N.D.N.D.N.D.0.10.1
M72.41.70.04N.D.1.21.2MSMS
M819.621.51.92.215.017.90.80.3
M9N.D.N.D.0.50.9N.D.N.D.0.20.04
M10N.D.N.D.0.10.1N.D.N.D.N.D.N.D.
M11N.D.N.D.0.10.1N.D.N.D.N.D.N.D.
Veliparib53.355.40.60.64441.1N.D.N.D.
OthersaN.D.N.D.N.D.N.D.N.D.N.D.0.20.1
Total recoveryb78.482.74.14.676.774.00.10.9
  • N.D., not detected; MS, detected by MS.

  • a Unidentified components.

  • b Total dose recovery is calculated from the sum of all quantifiable metabolites.