Metabolite | Retention Time | [M + H]+ (m/z) | Identity | Product Ions (m/z) |
---|---|---|---|---|
min | ||||
M6 | 16.1–16.2 | 402 | TZD ring-opened methyl sulfoxide amide | 161, 176 (B), 295, 321 |
M9 | 17.3–17.8 | 592 | TZD ring-opened N-glucuronide | 161, 176 (B), 282, 327, 373, 399, 416, 458 |
M10 | 18.1–18.6 | 418 | TZD ring-opened methyl sulfone amide | 161, 176 (B), 295, 321, 338 |
M11 | 18.9–19.1 | 464 | O-Demethyl-O-sulfate | 147, 162 (B), 242, 268, 384 |
M12 | 19.2–19.4 | 384 | O-Demethyl rivoglitazone | 147, 162 (B), 268, 313 |
M13 | 19.8 | 574 | N-Glucuronide | 161, 176 (B), 282, 398 |
M15 | 17.1 | 492 | TZD ring-opened S-cysteine conjugate | 161, 176 (B), 295, 340 |
M17 | 20.9–21.3 | 384 | N-Demethyl rivoglitazone | 147, 162 (B), 268, 313 |
M18 | 21.5–21.8 | 414 | TZD ring 5-hydroxy rivoglitazone | 161, 176 (B), 309, 354 |
M19 | 24.2–24.4 | 387 | TZD ring-opened methylmercapto carboxylic acid | 161, 176 (B), 282, 295 |
M20 | 20.4–20.9 | 386 | TZD ring-opened methylmercapto amide | 161, 176 (B), 281, 282, 294, 295 |
M21 | 16.3–16.6 | 356 | TZD ring-opened hydroxy amide | 161, 176 (B), 282, 311 |
M22 | 20.2 | 372 | TZD ring-opened mercapto amide | 161, 176 (B), 268, 282, 294, 327 |
M23 | 23.9 | 373 | TZD ring-opened mercapto carboxylic acid | 161, 176 (B), 268, 282, 295, 327 |
B, base peak.