TABLE 3

Correlation between irosustat metabolite formation in a panel of HLM from 16 different individual donors and specific activities of individual P450 enzymes and FMO3

Results are expressed as the Pearson correlation coefficient from the mean of duplicate incubations for each batch of HLM.

Enzymes^{^a}	Pearson Correlation Coefficient (r)
Enzymes^{^a}	M7	M8	M9	M11	M13	M14	M16	M18	P-36
CYP1A2 (a)	0.3442	0.2113	0.1063	−0.2011	0.1428	0.1566	0.1633	0.2141	0.1036
CYP1A2 (b)	0.3448	0.1842	0.1877	−0.0852	0.2512	0.3685	0.2702	0.1743	0.1871
CYP2A6	0.1461	0.1888	0.3843	0.2659	0.4432	0.4054	0.5487	0.4000	0.5040
CYP2B6 (c)	0.0842	0.0561	0.4763	0.4781	0.4743	0.5963	0.6118	0.2896	0.5014
CYP2B6 (d)	−0.2274	−0.2807	0.0828	0.3068	0.0793	0.2639	0.2399	−0.0511	0.3690
CYP2C8	0.5678	0.5420	0.7748^***	0.6891^**	0.6812^**	0.6607^**	0.7612^***	0.4732	0.5552
CYP2C9	0.8845^***	0.8734^***	0.7457^***	0.2617	0.7894^***	0.4010	0.6400^**	0.8397^***	0.5381
CYP2C19	0.7253^**	0.7077^**	0.5973	−0.0048	0.7237^**	0.4801	0.6592^**	0.8776^***	0.5918
CYP2D6	−0.1915	−0.0889	0.0417	−0.0502	0.1044	0.3233	0.1177	−0.0034	−0.3070
CYP2E1	0.6430^**	0.4251	0.5158	0.3324	0.3751	0.2590	0.3077	0.2424	0.3554
CYP3A4/5 (e)	0.2255	0.2284	0.5628	0.1269	0.6830^**	0.9490^***	0.7338^**	0.3922	0.3699
CYP3A4/5 (f)	0.2009	0.1563	0.5147	0.1804	0.6452^**	0.9273^***	0.7051^**	0.2731	0.4055
FMO3	−0.2383	−0.1785	−0.3982	−0.4268	−0.3530	−0.2174	−0.3755	−0.2916	−0.3942

↵*** Statistically significant correlation (P < 0.01).
↵*** Statistically significant correlation (P < 0.001).
↵a Enzyme activities: 7-ethoxyresorufin O-dealkylation (a) and phenacetin O-deethylation (b) (for CYP1A2); coumarin 7-hydroxylation (for CYP2A6); S-mephenytoin N-demethylation (c) and bupropion hydroxylation (d) (for CYP2B6); paclitaxel 6α-hydroxylation (for CYP2C8); diclofenac 4′-hydroxylation (for CYP2C9); S-mephenytoin 4′-hydroxylation (for CYP2C19); dextromethorphan O-demethylation (for CYP2D6); chlorzoxazone 6-hydroxylation (for CYP2E1); testosterone 6β-hydroxylation (e) and midazolam 1′-hydroxylation (f) (for CYP3A4/5); and benzydamine N-oxidation (for FMO3).