Cumulative recovery of radioactivity in urine, feces, cage wash, and bile after a 5 mg/kg i.v. or oral dose to BDC rats and a 2.5 mg/kg i.v. or oral dose to BDC dogs
Rat data are presented as the mean ± S.D.
| Animal | Route | Dose | Animal (n) | Recovery of Radioactivity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Time Point | Urine | Bile | Feces | Cage Wash | Total Recovery | ||||
| mg/kg | h | % dose | |||||||
| Rats | i.v. | 5 | 3 | 0–24 | 78.4 ± 7.0 | 4.5 ± 0.7 | 3.0 ± 1.2 | N.S. | 85.9 ± 5.1 |
| 0–72 | 79.3 ± 6.3 | 4.7 ± 0.7 | 3.7 ± 1.0 | 8.0 ± 3.1 | 95.7 ± 2.1 | ||||
| p.o. | 5 | 3 | 0–24 | 82.0 ± 8.8 | 4.9 ± 1.2 | 3.7 ± 1.0 | N.S. | 90.6 ± 6.6 | |
| 0–72 | 82.7 ± 8.4 | 5.1 ± 1.2 | 4.1 ± 1.1 | 5.7 ± 5.0 | 97.6 ± 1.2 | ||||
| Dogs | i.v. | 2.5 | 1 | 0–24 | 76.7 | 2.4 | 0.9 | 0.9 | 80.9 |
| 0–72 | 83.7 | 2.4 | 3.8 | 1.4 | 91.3 | ||||
| p.o. | 2.5 | 1 | 0–24 | 71.8 | 1.9 | 4.1 | 2.7 | 80.5 | |
| 0–72 | 74 | 1.9 | 4.9 | 3.5 | 84.3 | ||||
BDC, bile duct-cannulated; N.S., no sample.