TABLE 2

In vitro plasma protein binding of naronapride and its major metabolites (at pH 7.4, 37°C) across a range of test article concentrations

All experiments were conducted in triplicate. Plasma protein binding data are presented as means ± S.D.

Compound	Conc. Range	Range of Plasma Protein Binding
	μM	% bound
[¹⁴C]Naronapride	0.045–450	30 ± 3–41 ± 4
[¹⁴C]ATI-7500	0.064–640	25 ± 3–40 ± 4
ATI-7400	2.5–10	43 ± 1–44 ± 5
ATI-7100	2.5–10	65 ± 1–65 ± 2