CYP3A4 Model | P-gp Model | Combined Model | |
---|---|---|---|
CYP3A4 parameter estimates | |||
Vmax (nmol/s) | 54 | Not estimated | 48 |
Km (μM) | 0.64 | Not estimated | 0.54 |
P-gp parameter estimates | |||
Vmax (nmol/s) | Not estimated | 2.0 | 1.0 |
Km (μM) | Not estimated | 12.8 | 39 |
Objective measures | |||
R2 | 0.89 | 0.38 | 0.89 |
Akaikea | 389 | 688 | 346 |
Objective function | 4.65 | 15.2 | 3.93 |
↵a Akaike = nobservations × ln(objective function) + 2 × (nparameters).