EC50, Emax, and Hill coefficient (n) values of the inducers for CYP3A4 activity in human hepatocytes
Data from Shou et al. (2008) except for donor 3.
| Inducer | Donor | EC50 | Emax | n |
|---|---|---|---|---|
| μM | ||||
| Rifampin | 1 | 0.25 | 10.6 | 1.2 |
| 2 | 0.51 | 12.51 | 1.2 | |
| Carbamazepine | 1 | 15.3 | 15.73 | 2.1 |
| 2 | 27.7 | 4.57 | 2.6 | |
| 3 | 26.4 | 10.1 | 0.37 | |
| Phenobarbital | 1 | 250 | 22.65 | 0.9 |
| 2 | 120.3 | 8.65 | 1.4 |