Pharmacokinetic parameters of 5-MeO-DMT in wild-type mice after intravenous and intraperitoneal administration determined by noncompartmental analyses
| Intravenous Administration | Intraperitoneal Administration | |||||
|---|---|---|---|---|---|---|
| 2 mg/kg | 10 mg/kg | 20 mg/kg | 2 mg/kg | 10 mg/kg | 20 mg/kg | |
| AUC0→∞ (μmol · min/l) | 47.6 | 487 | 920 | 24.9 | 231 | 654 |
| AUC0→∞/dose (kg · min/l) | 5.19 | 10.6 | 10.0 | 2.71 | 5.03 | 7.13 |
| CL (l · min−1 · kg−1) | 0.19 | 0.094 | 0.10 | |||
| Vss (l/kg) | 2.27 | 2.08 | 1.84 | |||
| Tmax (min) | 3 | 5 | 5 | |||
| Cmax (μmol/l) | 1.31 | 7.00 | 15.8 | |||
| Cmax/dose (kg/l) | 0.14 | 0.15 | 0.17 | |||
| t1/2 (min) | 9.2 | 12 | 15 | |||
| F (%) | 52.2 | 47.3 | 71.0 | |||