TABLE 3

The intrinsic clearance for forming RMs

The intrinsic clearance for forming RMs was calculated from sum of CL_{int, RMs (GSH)} and CL_{int, RMs (TDI)}. CL_{int, RMs (GSH)} is the intrinsic clearance for forming RMs based on the formation rate of [³⁵S]GSH adducts, and CL_{int, RMs (TDI)} is the intrinsic clearance for forming RMs based on the enzyme inactivation rate in TDI assay.

Compound	CL_{int, RMs (GSH)}	CL_{int, RMs (TDI)}	CL_{int, RMs}
	μl · min⁻¹ · mg protein⁻¹
Acetaminophen	0.198	N.D.	0.198
Aminopyrine	N.D.	N.D.	N.D.
Amlodipine	N.D.	0.020	0.020
Amodiaquine	0.021	N.D.	0.021
Atorvastatin	0.127	N.D.	0.127
Benzbromarone	0.03	0.002	0.032
Caffeine	N.D.	N.D.	N.D.
Carbamazepine	N.D.	N.D.	N.D.
Celecoxib	N.D.	N.D.	N.D.
Clopidogrel	0.236	0.848	1.084
Clozapine	0.147	0.012	0.159
Diclofenac	0.01	N.D.	0.010
Donepezil	N.D.	N.D.	0.001
Erythromycin	N.D.	0.021	0.021
Ethinylestradiol	0.34	0.087	0.427
Fluoxetine	N.D.	0.008	0.008
Flutamide	0.02	N.D.	0.020
Furosemide	0.072	N.D.	0.072
Imipramine	0.012	N.D.	0.012
Indomethacin	N.D.	0.001	0.001
Levofloxacin	N.D.	N.D.	N.D.
Nevirapine	0.012	0.001	0.013
Olanzapine	0.113	0.006	0.119
Olmesartan	N.D.	N.D.	N.D.
Phenytoin	0.012	N.D.	0.012
Pioglitazone	N.D.	0.036	0.036
Pravastatin	N.D.	N.D.	N.D.
Procainamide	0.413	N.D.	0.413
Propranolol	0.027	0.004	0.031
Ritonavir	N.D.	3.550	3.550
Rosiglitazone	0.022	0.028	0.048
Sulfamethoxazole	0.213	N.D.	0.213
Tacrine	N.D.	0.007	0.007
Tamoxifen	N.D.	N.D.	N.D.
Ticlopidine	0.431	2.030	2.461
Tienilic acid	0.042	0.069	0.111
Valproic acid	N.D.	N.D.	N.D.
Valsartan	N.D.	N.D.	N.D.
Verapamil	0.048	0.026	0.074
Warfarin	N.D.	0.003	0.003
Zafirlukast	N.D.	0.207	0.207
Zomepirac	N.D.	N.D.	N.D.

N.D., not determined.