Pharmacokinetic parameters of L-368,899 in intravenously dosed male and female rats 1-a
| Dose (mg/kg) | N | AUC0–∞ (μg·hr/ml) | Clp (ml/min/kg) | Vdss (liters/kg) | t½ (hr) | MRT (hr) |
|---|---|---|---|---|---|---|
| 1.0 | ||||||
| Female | 4 | 0.52 ± 0.15 | 35 ± 12 | 2.0 ± 0.2 | 1.0 ± 0.2 | 1.0 ± 0.3 |
| Male | 4 | 0.56 ± 0.03 | 29 ± 2 | 2.0 ± 0.2 | 1.1 ± 0.1 | 1.1 ± 0.0 |
| 2.5 | ||||||
| Female | 3 | 1.7 ± 0.6 | 26 ± 7 | 2.1 ± 0.4 | 1.9 ± 0.5 | 1.4 ± 0.3 |
| Male | 4 | 1.2 ± 0.5 | 36 ± 12 | 2.6 ± 0.5 | 1.3 ± 0.4 | 1.3 ± 0.4 |
| 10 | ||||||
| Female | 3 | 9.5 ± 1.5 | 18 ± 3 | 2.0 ± 0.1 | 1.8 ± 0.3 | 1.9 ± 0.4 |
| Male | 4 | 5.3 ± 1.3 | 33 ± 8 | 2.1 ± 0.4 | 1.6 ± 0.2 | 1.1 ± 0.1 |
↵1-a Mean ± SD values listed.