Excretion of radioactivity in bile, urine and feces from female rats dosed with [14C]L-368,899 intravenously at 2.5 mg/kg or orally at 28 mg/kg
| Dosing Route | Time (hr) | % Dose3-a | ||
|---|---|---|---|---|
| Bile | Urine | Feces | ||
| IV | ||||
| 0–24 | 80.4 ± 3.4 | 6.1 ± 1.8 | 0.2 ± 0.2 | |
| 24–48 | 0.2 ± 0.2 | 0.8 ± 0.8 | 0.4 ± 0.4 | |
| 0–72 | 80.6 ± 3.3 | 7.0 ± 2.8 | 1.1 ± 0.9 | |
| PO | ||||
| 0–24 | 59.9 ± 5.6 | 9.4 ± 5.0 | 0.2 ± 0.3 | |
| 24–48 | 1.3 ± 0.4 | 2.8 ± 0.7 | 9.0 ± 11.2 | |
| 0–72 | 61.5 ± 5.4 | 12.7 ± 4.8 | 17.2 ± 11.7 | |
↵3-a Mean ± SD from three rats/dose.