KM and Vmaxvalues for the metabolism of L-368,899 in male and female rat liver microsomes
| Male | Female | |
|---|---|---|
| Rate (nmol/min/mg) | ||
| Concentration μ M | ||
| 0.5 | 0.09 ± 0.01 | 0.08 ± 0.03 |
| 1 | 0.12 ± 0.07 | 0.16 ± 0.02 |
| 1.5 | 0.21 ± 0.04 | 0.18 ± 0.04 |
| 2 | 0.31 ± 0.03 | 0.23 ± 0.04 |
| 5 | 0.40 ± 0.08 | 0.23 ± 0.18 |
| 10 | 0.71 ± 0.21 | 0.25 ± 0.07 |
| 15 | 0.52 ± 0.16 | —5-a |
| 25 | 0.69 ± 0.31 | —5-a |
| K M(μ M ) | 3.8 ± 1.4 | 0.81 ± 0.24 |
| V max(nmol/min/mg) | 0.79 ± 0.09 | 0.28 ± 0.02 |
| Cl int(ml/min/mg) | 0.21 ± 0.08 | 0.34 ± 0.11 |
↵5-a Not determined.