Table 1

Kinetic parameters for pravastatin transport

	Mean ± Computer Calculated SD
In vivo
Normal rats^1-a
K _{M, in vivo}(μM)	181 ± 78
V _{max, in vivo}(nmol/min/kg)	3440 ± 1410
P _{dif, in vivo} (ml/min/kg)	4.92 ± 1.58
EHBRs^1-b
K _{M, in vivo} (μM)	—
V _{max, in vivo}(nmol/min/kg)	—
P _{dif, in vivo} (ml/min/kg)	1.45 ± 0.07
In vitro (normal rats)
In the presence of ATP^1-c
K _{M, in vitro}(μM)	262 ± 45.3
V _{max, in vitro} (pmol/min/mg protein)	2870 ± 470
P _{dif, in vitro} (μl/min/mg protein)	1.85 ± 0.15
In the absence of ATP^1-c (ATP-independent uptake)
K _{M, in vitro} (μM)	477 ± 99
V _{max, in vitro} (pmol/min/mg protein)	1000 ± 221
P _{dif, in vitro} (μl/min/mg protein)	1.68 ± 0.70
ATP-dependent uptake^1-d
K _{M, in vitro} (μM)	223 ± 29
V _{max, in vitro} (pmol/min/mg protein)	1960 ± 224
P _{dif, in vitro} (μl/min/mg protein)	0.159 ± 0.045
Inhibition on ATP-dependent DNP-SG uptake^1-e
K_i (μM)	172 ± 38

↵1-a Data shown in Fig. 3(a).
↵1-b Data shown in Fig. 3(b).
↵1-c Data shown in Fig. 5(a).
↵1-d Data shown in Fig. 5(b).
↵1-e Data shown in Fig. 6.