Table 1

Mean (SD) model parameter and secondary parameter estimates for VEN and ODV obtained using first-pass model after oral administration of a single dose (1.5 mg/kg) of VEN to human subjects

ParameterEstimate
CL int(liters/hr)1-a 65.8  ± 39.7
RL 1-b 29.6  ± 18.3
V VEN (liters)252  ± 87.6
CL ODV (liters/hr)23.5  ± 12.5
V ODV (liters)181  ± 84.1
ka (hr−1)1.31  ± 0.009
E1-c 0.40  ± 0.13

  • See text for abbreviations.

  • ↵1-a CLint, Intrinsic hepatic clearance of VEN.

  • ↵1-b RL , Liver:plasma partition coefficient for VEN.

  • ↵1-c E, Hepatic extraction ratio =CLint/(Q +CLint).