Table 2

Mean (SD) pharmacokinetic parameters for VEN and ODV using noncompartmental analysis after oral administration of a single dose (1.5 mg/kg) of VEN to human subjects

Parameter	VEN	ODV
AUC (ng-hr/ml)^2-a	2370 ± 734	3753 ± 700
k(hr⁻¹)	0.127 ± 0.033	0.064 ± 0.013
CL (liters/hr)	59.6 ± 26.5^2-b	19.2 ± 2.7^2-c
V (liters)	459 ± 92^2-d	309 ± 60^2-e

See text for abbreviations.
↵2-a AUC(0 − ∞) calculated using the trapezoidal rule.
↵2-b CL_int =D/AUC_ven.
↵2-c CL/f_m =D/AUC_odv.
↵2-d V/F =CL_ven/k_ven.
↵2-e V/f_m =CL_odv/k_odv.