Table 3

Octanol/buffer partition coefficients (log P) and extent of protein binding of the inhibitors

Inhibitor	Octanol (%)	Buffer (%)	Log P	Protein Bound Fraction (%)
Inhibitor	Octanol (%)	Buffer (%)	Log P	Peak 1^3-a	Peak 2^3-a
R-Hep	0	100	≪	21	9
Et-R-Hep	74	26	0.45	17	9
Pt-R-Hep	93	7	1.12	75	40
Do-R-Hep	100	0	≫	–^3-b	–^3-b
DiEt-R-Hep	91	9	1.00	19	9

↵3-a Peaks 1 and 2 correspond to the diastereomers eluting in that order from the HPLC column.
↵3-b Protein binding could not be determined, because the compound formed a suspension.