Table 3

Cumulative urinary excretion of FIN and its metabolites after oral administration of [¹⁴C]FIN

Animal	Dose Group	Interval	% of Dose Excreted as
			¹⁴C^3-a	FIN	Metabolite
			¹⁴C^3-a	FIN	I	II	Diols^3-b	IV	Acidic^3-c
	mg/kg	hr
Dog 1	10	0–24	4.4	0.02	0.63	ND	1.4	0.1	0.3
	80	0–72	4.7	0.15	1.3	0.2	1.7^3-d	0.1	0.2^3-e

Dog 2	80	0–72	2.9	0.05	0.23	0.1	1.5^f	0.1	0.2^3-g

↵3-a Values represent the recoveries of the radioactive doses in the collection intervals.
↵3-b Values represent the total excretion of dihydoxy metabolites (V, VI, and VII) hydroxylated on the side chain and also on the tetracyclic ring system.
↵3-c Metabolites characterized as acidic on the basis of solvent partition data.
↵3-d Metabolite V in this fraction accounted for nearly 60% of the radioactivity.
↵3-e Metabolite V in this fraction was identified tentatively.
3-f Metabolites V, VI, andVII each accounted for 20–30% of the radioactivity in this fraction.
↵3-g Metabolite VII in this fraction accounted for nearly 80% of the radioactivity.