Correlation of the formation of 5-HOS with isoform-specific CYP activities
| Activity | Correlation Coefficient (r) | |||||||
|---|---|---|---|---|---|---|---|---|
| 5-HOS | ERODase | COHase | TOLase | MPHase | DEXase | DMNase | ERNDase | |
| ERNDase | 0.885** | 0.089 | 0.667* | 0.480 | 0.811** | 0.322 | 0.322 | 1.000 |
| DMNase | 0.022 | 0.359 | 0.020 | 0.084 | 0.081 | 0.027 | 1.000 | |
| DEXase | 0.538 | 0.732* | 0.215 | 0.848* | 0.351 | 1.000 | ||
| MPHase | 0.954*** | 0.061 | 0.761* | 0.572 | 1.000 | |||
| TOLase | 0.696* | 0.444 | 0.546 | 1.000 | ||||
| COHase | 0.670* | −0.286 | 1.000 | |||||
| ERODase | 0.238 | 1.000 | ||||||
| 5-HOS | 1.000 | |||||||
ERODase, ethoxyresorufin O-demethylase; COHase, coumarin 7-hydroxylase; TOLase, tolbutamide methylhydroxylase; MPHase,S-mephenytoin 4′-hydroxylase; DEXase, dextromethorphanO-demethylase; DMNase,N,N-dimethylnitrosamine N-demethylase; ERNDase, erythromycin N-demethylase. N = 10 (microsomes from 10 different livers as in fig. 2).
p values are as follows: * p < 0.05; ** p < 0.01; *** p < 0.001.