Effect of NADPH and NADH on APAP-3-GSH formation in adult male rat microsomes
| (APAP-3-GSH formed) | |
|---|---|
| (nmol prod/min/mg protein) | |
| NADPH (μM) | |
| 100 | 0.129 ± 0.003 |
| 500 | 0.346 ± 0.004 |
| 3000 | 0.385 ± 0.007 |
| NADH (μM) | |
| 100 | ND4-a |
| 500 | ND4-a |
| 3000 | 0.114 ± 0.005 |
| NADH/NADPH | |
| 400/100 | 0.225 ± 0.005 |
Acetaminophen concentration was 1 mM. Values are mean ± SD,N = 3.
↵4-a ND, not detectable.