Addition | Me-OH lidocaine formation4-a nmol/min/mg | MEGX formation4-b nmol/min/mg | ||
---|---|---|---|---|
Time 04-c | Time 5 | Time 0 | Time 5 | |
None | 8.1 ± 0.3 (100) | 7.6 ± 0.7 (94) | 61.4 ± 2.7 (100) | 59.5 ± 1.9 (97) |
2EN | 4.5 ± 0.2 (56) | 3.8 ± 0.3 (47) | 38.7 ± 0.3 (63) | 26.1 ± 2.6 (43) |
9EPh | 7.1 ± 0.3 (88) | 2.3 ± 0.1 (28) | 39.1 ± 0.6 (64) | 24.4 ± 0.62 (40) |
Incubation conditions and analysis of the products were as described under Materials and Methods. The values represent the average ± SD from three determinations. The numbers in parentheses represent the percentage of activity relative to the control incubation at time 0.