Table 5

Effect of 9EPh on testosterone metabolism in microsomes from untreated and PB-treated rats

Inducer	9EPh	Testosterone metabolism (nmol/min/mg protein)
Inducer	9EPh	6β/7α	16-keto	16α	16β	2α	2β	17^5-a
None	−	2.11 ± 0.13	ND^5-b	2.61 ± 0.19	<0.0025	1.22 ± 0.08	<0.0025	0.85 ± 0.06
None	+	1.32 ± 0.10	ND	2.44 ± 0.06	ND	1.16 ± 0.05	ND	0.88 ± 0.09
		(63)^*		(93)		(95)		(104)
PB	−	3.72 ± 0.09	2.51 ± 0.13	4.84 ± 0.12	3.46 ± 0.33	0.1^5-c	0.27 ± 0.04	1.05 ± 0.15
PB	+	3.87 ± 0.36	0.22 ± 0.1	1.88 ± 0.05	1.00 ± 0.18	0.24 ± 0.06	0.33 ± 0.03	1.12 ± 0.18
		(104)	(8.8)^**	(39)^***	(29)^**	(240)	(122)	(107)

Testosterone metabolism by liver microsomes from untreated or PB-treated rats in the presence or absence of 20 μM 9EPh. Analysis of metabolites was as described under Materials and Methods. The values represent the mean ± SD from three determinations. The numbers in parentheses represent the percentage of testosterone activity relative to the incubations without 9EPh. ^* p< 0.05, ^** p < 0.002, ^*** p < 0.001.

↵5-a 17-Oxidation, androstenedione formation.
↵5-b ND, not detected.
↵5-c Only one determination.