Rate of CI-976 (50 μM) and M-1 (25 μM) disappearance in freshly isolated hepatocytes from male and female rats
| Gender/Treatment | Rate of CI-976 Disappearance2-a | Rate of M-1Disappearance2-a |
|---|---|---|
| Male | 0.40 ± 0.102-b | 0.63 ± 0.202-c |
| (N = 7) | ||
| Male PB control | 0.56 ± 0.072-b | 0.69 ± 0.152-b |
| (N = 3) | ||
| Male PB induced | 0.91 ± 0.192-c | 1.33 ± 0.112-b |
| (N = 3) | ||
| Male CF control | 0.36 ± 0.172-c | 0.43 ± 0.122-d |
| (N = 3) | ||
| Male CF induced | 1.49 ± 0.132-d | 2.48 (2.30, 2.66)2-e , 2-d |
| (N = 3) | ||
| Female | 0.14 ± 0.052-b | 0.73 ± 0.28 |
| (N = 3) |
Values are means ± SD. PB, phenobarbital; CF, clofibrate.
↵2-a Nmol/min/106 cells.
↵2-b p < 0.01 between male and female (CI-976) and PB control and induced (M-1).
↵2-c p < 0.05 between PB control and induced (CI-976) and the rate of CI-976 and M-1disappearance.
↵2-d p < 0.001 between CF control and induced (both CI-976 and M-1).
↵2-e Mean of two values.