N-Hydroxylation of guanabenz to guanoxabenz in 10 different samples of human hepatic microsomes
| Human Liver Sample | pmol Guanoxabenz/min × nmol P450 |
|---|---|
| HBI 2 | 94 ± 4 |
| HBI 3 | 202 ± 2 |
| HBI 5 | 61 ± 6 |
| HBI 6 | 21 ± 1 |
| HBI 7 | 192 ± 10 |
| HBI 9 | 43 ± 8 |
| HBI 10 | 25 ± 2 |
| HBI 11 | 404 ± 27 |
| HBI 12 | 11 ± 3 |
| HBI 13 | 75 ± 7 |
For incubation procedure, sample work-up, and analysis seeMaterials and Methods.
Values are presented as the mean ± SE of a minimum of four different determinations.