Table 1

Toxicokinetic experimental design

Group	No. Mice	Dose Level (mg/kg/inj)	Sampling Times
Group	No. Mice	Dose Level (mg/kg/inj)	Day 0 (Dose 1)	Day 14 (Dose 8)	Day 28 (Dose 15)
1	36	0.8	2, 90 min; 24, 48, 96 hr	2 min; 24, 96 hr	2 min; 24, 96 hr
2	72	4	2, 5, 10, 20, 45, 90, 180, 300 min; 24, 48, 96 hr	2 min; 24, 96 hr	2, 5, 10, 45, 90, 180, 300 min; 24, 96 hr
3	72	20	2, 5, 10, 20, 45, 90, 180, 300 min; 24, 48, 96 hr	2 min; 24, 96 hr	2, 5, 10, 45, 90, 180, 300 min; 24, 96 hr
4	62	100	2, 90, 180, 300 min; 24, 48, 96 hr	2 min; 24, 96 hr	2 min; 24, 96 hr