Table 3

CGP 69846A elimination half-life estimates (in hours) following single iv administration over a dose range of 0.8 to 100 mg/kg

OrganDose (mg/kg)
0.8420100
Kidney26314440
Liver41333760
Lung—3-a —2333
Heart——2416
Lymph Node3-b ——2623
Spleen——2124

  • ↵3-a Not calculated due to lack of assay sensitivity to measure concentrations in tissue at this dose.

  • ↵3-b Mesenteric.