C b | Total concentration of drug in total brain tissue |
C b * | Total concentration of labeled drug in total brain tissue |
C e | Concentration of drug in the extracellular fluid |
C e * | Concentration of radiolabeled drug in the extracellular fluid |
C i | Concentration of drug in the intracellular space |
C in * | Perfusate concentration of labeled drug entering the ventricles |
C out | Perfusate concentration of unlabeled drug in the cisternal outflow |
C out * | Perfusate concentration of labeled drug in the cisternal outflow |
C p | Concentration of drug in the plasma water |
C v | Average concentration of drug in ventricular fluid |
C v * | Average concentration of radiolabeled drug in ventricular fluid |
f e | Extracellular fractional volume of brain tissue |
f i | Intracellular fractional volume of brain tissue |
K ei | Rate constant for drug transfer from the extracellular fluid to the intracellular space |
K ep | Rate constant for drug transfer from the extracellular fluid to the plasma water |
K ev | Rate constant for drug transfer from the extracellular fluid to the ventricles |
K ie | Rate constant for drug transfer from the intracellular space to the extracellular fluid |
K pe | Rate constant for drug transfer from the plasma water to the extracellular fluid |
K ve | Rate constant for drug transfer from the ventricles to the extracellular fluid |
Q | Perfusion flow rate of mock CSF through the ventricles |
V e | Volume of extracellular space |
V i | Volume of intracellular space |
V v | Volume of ventricular space |