Parameter | Control | Probenecid | Statistical Significance | Model Equation | Mechanism |
---|---|---|---|---|---|
Brain/cisternal concentration ratio for unlabeled drug (C b/C v) | 0.82–1.34 | 2.91–4.33 | p < 0.05 in nine of ten regions | K ei/K ie[PBD] > K ei/K ie[control] | |
Brain/ventricle concentration ratio for labeled drug (C b */C v *) | 0.035–0.122 | 0.085–0.294 | NS7-a in all regions | K ei/K ie[PBD] > K ei/K ie[control] and K ep [PBD] ≈ or >K ep [control] | |
Brain/free plasma concentration ratio for unlabeled drug (C b/C p) | 0.085–0.138 | 0.358–0.545 | p < 0.01 in eight of ten regions | K pe[PBD] > K pe [control]K ei/K ie[PBD] > K ei/K ie[control] |
↵7-a NS, not significant.