Mean (±SD) amount (μg) of M1, M2, andM4, excreted in 24-hr urine after iv administration of DA-125 (20 mg/kg body weight) to SHRs, Kyoto-Wistar (KW) rats, DOCA-salt rats, and Sprague-Dawley (SD) rats at 16 weeks old (N = 5 each) before and after incubation with β-glucuronidase
| M1 | M2 | M4 | ||||
|---|---|---|---|---|---|---|
| SHRs | KW Rats | SHRs | KW Rats | SHRs | KW Rats | |
| Before | 3.43 ± 0.900 | 1.78 ± 1.95 | 290 ± 77.9 | 170 ± 149 | 18.1 ± 17.5 | 12.7 ± 9.58 |
| After | 5.42 ± 2.19** | 2.41 ± 2.59 | 354 ± 93.4 | 173 ± 154 | 76.4 ± 48.6 | 30.3 ± 28.1 |
| M1 | M2 | M4 | ||||
|---|---|---|---|---|---|---|
| DOCA-salt Rats | SD Rats | DOCA-salt Rats | SD Rats | DOCA-salt Rats | SD Rats | |
| Before | 18.7 ± 7.13 | 18.6 ± 4.07 | 62.7 ± 45.7 | 108 ± 26.7 | UD7-a | 1.72 ± 1.59 |
| After | 40.7 ± 13.1 | 26.0 ± 7.03 | 63.7 ± 46.2 | 103 ± 24.9 | 13.7 ± 5.09 | 18.7 ± 4.75 |
↵7-a UD, under detection limit.
p value is as follows: ** p < 0.01.