Calculated pharmacokinetic parameters of OLZ after the administration of a single dose of [14C]OLZ
| Subject No. | Cmax | tmax | k | r | t1/2 | AUC0 to t | AUC0 to inf | CLs/F | V/F |
|---|---|---|---|---|---|---|---|---|---|
| ng/ml | hr | hr | hr | ng*hr/ml | ng*hr/ml | liters/hr | liters | ||
| 1 | 9.6 | 8.00 | 0.0275 | 0.990 | 25.2 | 314 | 320 | 38.0 | 1383 |
| 2 | 10.2 | 4.50 | 0.0247 | 0.988 | 28.0 | 266 | 279 | 43.5 | 1760 |
| 3 | 12.5 | 3.00 | 0.0286 | 0.995 | 24.2 | 279 | 287 | 42.4 | 1483 |
| 4 | 10.2 | 4.00 | 0.0253 | 0.996 | 27.4 | 248 | 255 | 47.8 | 1887 |
| 5 | 10.1 | 6.00 | 0.0248 | 0.954 | 27.9 | 257 | 263 | 46.2 | 1863 |
| 6 | 10.4 | 4.00 | 0.0267 | 0.968 | 26.0 | 250 | 260 | 46.8 | 1756 |
| Mean | 10.5 | 4.92 | 0.0263 | 0.982 | 26.5 | 269 | 277 | 44.1 | 1689 |
| SD | 1.0 | 1.80 | 0.0016 | 0.017 | 1.6 | 25 | 24 | 3.6 | 207 |
| CV (%) | 9.7 | 36.6 | 6.0 | 1.7 | 5.9 | 9.2 | 8.8 | 8.2 | 12.3 |
Cmax, maximum plasma concentration;tmax, time at maximum concentration;k, elimination rate constant; r, coefficient of correlation of the log–linear phase of the concentrationvs. time curve; t1/2, terminal half-life; CLs/F, apparent systemic clearance;V/F, apparent volume of distribution; CV, coefficient of variation.