Calculated pharmacokinetic parameters of radioactivity after the administration of a single dose of [14C]OLZ
| Subject No. | Cmax | tmax | k | r | t1/2 | AUC0 to t | AUC0 to inf |
|---|---|---|---|---|---|---|---|
| ng/eq/ml | hr | hr−1 | hr | ng eq*hr/ml | ng eq*hr/ml | ||
| 1 | 65.8 | 5.00 | 0.0119 | 0.987 | 58.1 | 2829 | 3391 |
| 2 | 32.6 | 5.00 | 0.0109 | 0.996 | 63.4 | 1978 | 2489 |
| 3 | 33.7 | 4.50 | 0.0102 | 0.994 | 68.2 | 1860 | 2413 |
| 4 | 43.4 | 4.00 | 0.0125 | 0.983 | 55.6 | 1653 | 1961 |
| 5 | 26.3 | 6.00 | 0.0146 | 0.990 | 47.3 | 1368 | 1563 |
| 6 | 32.4 | 5.00 | 0.0116 | 0.996 | 59.6 | 2080 | 2568 |
| Mean | 39.0 | 4.92 | 0.0120 | 0.991 | 58.7 | 1961 | 2398 |
| SD | 14.2 | 0.66 | 0.0015 | 0.005 | 7.1 | 495 | 618 |
| CV (%) | 36.4 | 13.5 | 12.9 | 0.5 | 12.1 | 25.2 | 25.8 |
Cmax, maximum plasma concentration;tmax, time at maximum concentration;k, elimination rate constant; r, coefficient of correlation of the log–linear phase of the concentrationvs. time curve; t1/2, terminal half-life; CV, coefficient of variation.