Pharmacokinetic parameters for CZX metabolism were assessed for each individual by quantifying CZX and its metabolite, 6-OH-CZX, after oral administration of 500 mg. Quantification was by an HPLC-based assay described in Materials and Methods. Values are mean ± SE of three separate determinations.
| Subject | Clearance | CZX Cmax | 6-OH-CZXCmax | CZX AUC | 6-OH-CZX AUC | 6-OH-CZX/CZX AUC Ratio |
|---|---|---|---|---|---|---|
| liters/hr | μg/ml | μg/ml | μg/ml/hr | μg/ml/hr | ||
| Male control (5)1-a | 21.31 ± 2.74 | 5.59 ± 0.58 | 0.47 ± 0.09 | 25.48 ± 4.04 | 2.83 ± 0.24 | 0.12 ± 0.01 |
| Female control (6) | 23.31 ± 3.65 | 6.12 ± 0.38 | 0.46 ± 0.03 | 23.94 ± 3.39 | 3.22 ± 0.16 | 0.15 ± 0.02 |
| Control (11) | 22.40 ± 2.26 | 5.89 ± 0.32 | 0.43 ± 0.02 | 24.64 ± 2.49 | 3.04 ± 0.15 | 0.13 ± 0.01 |
| Male alcohol abuser (5) | 47.60 ± 14.58 | 4.60 ± 0.56 | 0.62 ± 0.10 | 13.11 ± 2.14 | 3.19 ± 0.29 | 0.31 ± 0.10 |
| Female alcohol abuser (6) | 43.20 ± 4.41 | 4.18 ± 0.78 | 0.56 ± 0.09 | 12.11 ± 1.18 | 2.95 ± 0.20 | 0.26 ± 0.04 |
| Alcohol abuser (11) | 45.29 ± 6.651-b | 4.37 ± 0.481-b | 0.58 ± 0.071-b | 12.56 ± 1.111-b | 3.06 ± 0.10 | 0.29 ± 0.051-b |