Table 1

Amounts of TNP-470 metabolite formed in different monkey tissue microsomes after incubation of 50 μM [3H]TNP-470 (specific activity, 4.4 dpm/pmol) and 10 MM NADPH at 37°C, for 15 min, in the presence of 0.1 mg/ml microsomal protein.

CompoundsDrug Concentrations
LiverIntestineKidneyLungsControl
nmol/mg of protein
TNP-4709.382.3120.5238.8283.5
M-I35.60.025.60.00.0
M-II9.45.9126.80.00.0
M-III28.00.00.00.00.0
M-IV260.0254.168.4103.558.8

Each value represents the mean of two independent experiments.