Table 4

Metabolites identified in bile, urine and plasma after the oral administration of tenidap

Metabolite^4-a	Percent of Dose		Presence^4-b in Plasma
Metabolite^4-a	Bile	Urine	Presence^4-b in Plasma
Tenidap	0.8	1.0	+
A, 5′hydroxy TP	35^4-c	0.3
B, 3′ or 4′-hydroxy TP	5^4-c
C, 6-hydroxy TP	12^4-c	0.4
D, 4, 5 or 7-hydroxy TP	2.7^4-c
E, 3′ or 4′-hydroxy TP	2.3^4-c	1.0
F, hydroxymethoxy TP	4	1.4
G, 3′-hydroxysulfate TP	—	—	+^4-d
H, descarboxamidohydroxy TP	3
I, descarboxamidohydroxy TP	1.5
K, descarboxamido TP	0.8^4-e
L, thionocarboxylic acid metabolite		0.6
P, TP-5′-thiolactone			+
X, 3′,4′-dihydroxy TP	3
Y, 2′-hydroxy-TP-5′-thiolenone			+
Total	72.4	4.7