Pharmacokinetic parameters after oral administration of [14C]D2916 at 20 mg/kg to male and female rats
| Tissue | Male Rats | Female Rats | ||
|---|---|---|---|---|
| t1/2 (elimination) | AUC (0 → ∞) | t1/2 (elimination) | AUC (0 → ∞) | |
| hr | hr × nmol/g | hr | hr × nmol/g | |
| Blood | 1.19 ± 0.20 | 228 ± 29 | 3.39 ± 0.36 | 465 ± 42 |
| Plasma | 1.23 ± 0.15 | 289 ± 38 | 3.88 ± 0.56 | 520 ± 46 |
| Liver | 1.79 ± 0.25 | 691 ± 56 | 3.46 ± 0.28 | 1092 ± 105 |
| Kidney | 0.91 ± 0.12 | 601 ± 60 | 3.62 ± 0.35 | 896 ± 57 |
| Heart | 1.28 ± 0.9 | 196 ± 41 | 3.14 ± 0.22 | 463 ± 50 |
| Lung | 1.04 ± 0.17 | 221 ± 20 | 3.49 ± 0.40 | 454 ± 29 |
| Brain | 1.41 ± 0.28 | 126 ± 14 | 3.49 ± 0.39 | 468 ± 47 |
| Fat | 2.00 ± 0.46 | 481 ± 96 | 3.68 ± 0.45 | 1408 ± 241 |
Values are the means for five animals ± SD. For all tissues, t1/2 (males) <t1/2 (females): p < 0.05; AUC (males) < AUC (females): p < 0.05.