Tissue distribution of radioactivity after oral administration of14C-labeled D2916 at 20 mg/kg to female rats
| Tissue | Time after Administration | ||||||
|---|---|---|---|---|---|---|---|
| 15 min | 30 min | 1 hr | 2 hr | 6 hr | 16 hr | 24 hr | |
| Blood | 18.6 ± 5.7 | 20.1 ± 12.9 | 48.1 ± 10.9 | 60.1 ± 15.6 | 28.3 ± 16.7 | 4.7 ± 1.4 | 3.1 ± 0.4 |
| Plasma | 22.0 ± 7.8 | 22.5 ± 14.2 | 55.4 ± 10.7 | 63.4 ± 18.2 | 29.9 ± 17.9 | 5.3 ± 1.8 | 3.8 ± 0.3 |
| Liver | 50.8 ± 34.8 | 71.9 ± 20.4 | 125.1 ± 18.6 | 140.9 ± 61.0 | 65.1 ± 28.4 | 11.9 ± 6.0 | 6.5 ± 1.5 |
| Kidney | 45.0 ± 28.6 | 61.6 ± 28.2 | 82.6 ± 17.1 | 97.6 ± 29.8 | 46.9 ± 19.2 | 13.9 ± 4.2 | 8.2 ± 1.1 |
| Heart | 20.4 ± 7.2 | 30.5 ± 8.2 | 49.1 ± 8.5 | 63.3 ± 17.2 | 29.9 ± 17.1 | 3.7 ± 1.6 | 2.3 ± 0.3 |
| Lung | 18.1 ± 11.5 | 25.1 ± 5.9 | 55.4 ± 6.6 | 60.5 ± 17.0 | 27.6 ± 15.7 | 4.5 ± 1.7 | 2.6 ± 0.4 |
| Brain | 15.0 ± 5.1 | 17.5 ± 10.4 | 45.3 ± 9.7 | 51.7 ± 12.8 | 24.7 ± 14.8 | 3.1 ± 1.3 | 2.0 ± 0.3 |
| Fat | 55.1 ± 23.4 | 84.1 ± 27.7 | 166.8 ± 61.9 | 181.9 ± 52.1 | 49.9 ± 19.4 | 10.9 ± 2.8 | 4.5 ± 0.6 |
Values, given in nmol-eq of D2916/g of tissue, are the means ± SD for five animals.