HPLC analysis of urinary metabolites after oral administration of a single dose of 20 mg/kg [14C]D2916 to male and female rats
| Time after Administration | D3187 | D3269 | D3342 | D3389 + Unknown Metabolites | ||||
|---|---|---|---|---|---|---|---|---|
| Males | Females | Males | Females | Males | Females | Males | Females | |
| hr | ||||||||
| 0–3 | 3.5 | 15.6 | 22.6 | 55.8 | 8.5 | 2.7 | 58.2 | 19.5 |
| 3–6 | 1.1 | 10.4 | 26.2 | 65.3 | 4.2 | 1.8 | 52.8 | 16.5 |
| 6–24 | 0.9 | 7.5 | 20.5 | 70.1 | 2.4 | 2.0 | 71.2 | 15.7 |
| 24–48 | 0 | 4.1 | 14.7 | 75.6 | 1.4 | 1.5 | 79.8 | 14.8 |
Results, given in percentage of urinary radioactivity, are obtained from a pool of five rats.