Table 1

Quantitation of nicotine and its metabolites in brain after sc administration of S-(−)-[³H-methyl]nicotine in rats

Time in Min^1-a	fmol in Brain^1-b
Time in Min^1-a	Peak A^1-c	Cotinine	Nicotine
5 (5)^1-d	45.9 ± 7.8	ND^1-e	334.3 ± 40.0
30 (4)	158.4 ± 5.9	103.8 ± 4.2	841.8 ± 30.4
60 (7)	121.6 ± 19.7	124.6 ± 12.5	1039.1 ± 228.0
240 (5)	161.7 ± 20.0	201.4 ± 13.8	165.7 ± 46.1
480 (4)	216.1 ± 13.1	121.9 ± 13.6	ND
1080 (7)	118.6 ± 16.3	40.8 ± 3.8	ND

↵1-a Time after administration (sc) ofS-(−)-[³H-methyl]nicotine.
↵1-b Data are presented as the mean ± SEM.
↵1-c Assumes stoichiometric transfer of radiolabel.
↵1-d Number of animals is indicated in parentheses.
↵1-e ND, not detectable.