Table 1

Kinetic parameters of theophylline administered intravenously (2.5 mg/kg) to conscious rabbits

	AUC_T(0-∞)	CL	V_SS	t_½
	μg·min/ml	ml/min/kg	ml/kg	min
Control + theophylline	1117 ± 155	2.4 ± 0.3	585 ± 18	182 ± 19
l-NAME + theophylline	1935 ± 145^*	1.3 ± 0.1^*	543 ± 38	298 ± 35^*
l-arginine + theophylline	1855 ± 176^*	1.4 ± 0.1^*	530 ± 28	275 ± 35^*

Values are means ± SE. AUC_T(0-∞), area under theophylline plasma concentrations vs. time;CL, theophylline systemic clearance;V_SS, predicted volume of distribution of theophylline at steady-state; t_½, theophylline terminal half-life. * p < 0.05, compared with control rabbits.