Mean (±SD) values of AUCT and amount of M1,M2, M3, M4 excreted in 24-hr urine after iv administration of DA-125 (20 mg/kg body weight) to 6-week-old SHRs and their age-matched control Kyoto-Wistar (KW) rats
| SHRs (N = 5) | KW Rats (N = 6) | |||||||
|---|---|---|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M1 | M2 | M3 | M4 | |
| AUCT (μg-min/ml) | 112 ± 29.5 | 85.4 ± 96.1 | 29.3 ± 6.83 | 161 ± 43.7 | 58.0 ± 21.7 | 18.7 ± 15.8*** | 42.8 ± 12.4 | |
| Amount excreted in 24-hr urine2-a (μg) | 7.59 ± 4.40 | 132 ± 47.3 | 1.66 ± 0.168 | 27.7 ± 15.7 | 7.80 ± 5.21 | 142 ± 77.4 | 2.11 ± 0.667 | 69.9 ± 36.3 |
| % of dose excreted in 24-hr urine2-a | 0.310 ± 0.221 | 5.40 ± 2.37 | 0.0675 ± 0.0118 | 1.12 ± 1.05 | 0.311 ± 0.250 | 5.65 ± 3.65 | 0.0838 ± 0.0454 | 2.75 ± 2.33 |
| CL (ml/min/kg) | 150 ± 33.1* | 104 ± 33.0 | ||||||
| CLR (ml/min/kg) | 0.0292 ± 0.0657 | 0.664 ± 2.58 | 0.274 ± 0.684 | 0.0261 ± 0.0287 | 1.03 ± 1.61 | 0.0767 ± 0.239*** | 0.185 ± 1.40 | |
↵2-a Expressed in terms of DA-125.
p values are as follows: * p < 0.05; *** p < 0.001.