Metabolites | Lidocaine Concentration (μM) | Formation Rates of Metabolites2-b (nmol/min/mg protein) | |
---|---|---|---|
UT Group | PB Group | ||
MEGX2-c | 10 | 1.02 ± 0.07 | 5.14 ± 0.492-e |
100 | 2.98 ± 0.39 | 13.47 ± 1.622-e | |
3-OH LID2-d | 10 | 0.64 ± 0.07 | 0.58 ± 0.03 |
100 | 0.59 ± 0.06 | 0.56 ± 0.04 |
↵2-a Values are expressed as mean ± SE of eight experiments for each group.
↵2-b The reaction mixture containing hepatic microsomes from untreated (UT) and phenobarbital-treated (PB) rats (50 μg), NADPH (0.4 mM), and lidocaine was incubated for 10 min at 37°C in 0.1 M potassium phosphate buffer, pH 7.4.
↵2-c MEGX, monoethylglycinexylidide.
↵2-d 3-OH LID, 3-hydroxylidocaine.
↵2-e p < 0.001, comparison with values obtained for untreated group.