Pharmacokinetic parameters for total radioactivity and ZIP in LE rat plasma
| Animals2-a | ZIP and Total Radioactivity | Pharmacokinetic Parameters | ||
|---|---|---|---|---|
| Cmax | AUC (0–12) | tmax | ||
| ng equivalents/ml | ng equivalents·hr/ml | hr | ||
| Male rats | 14C radioactivity | 1897.5 | 5934.9 | 1 |
| 3H radioactivity | 1932.0 | 6554.0 | 1 | |
| ZIP | 981.6 | 2545.5 | 1 | |
| % of ZIP2-b | 51.3 | 40.8 | ||
| Female rats | 14C radioactivity | 2374.5 | 8877.4 | 1 |
| 3H radioactivity | 2459.0 | 9560.8 | 1 | |
| ZIP | 1435.1 | 4428.8 | 1 | |
| % of ZIP2-b | 59.4 | 48.0 | ||