Apparent pharmacokinetic parameters of 4-ene VPA and α-fluoro-4-ene VPA in rats
| Parameter | 4-Ene VPA2-a | α-F-4-ene VPA2-a |
|---|---|---|
| Cmax(μmol/mL) | 2.34 ± 0.44 | 2.58 ± 0.15 |
| K (min−1)2-b | 0.0259 ± 0.0035 | 0.0173 ± 0.0007 |
| t1/2(min)2-b | 27.1 ± 3.7 | 40.2 ± 1.3 |
| AUC (μmol · min/mL)2-c | 194.8 ± 27.5 | 206.1 ± 16.6 |
| CLip (mL/min · kg)2-c | 7.29 ± 1.00 | 6.83 ± 0.55 |
↵2-a Rats were dosed i.p. with either 4-ene VPA or α-fluoro-4-ene VPA at 1.4 mmol/kg. The data were expressed as mean ± S.D. (N = 4).
↵2-b The apparent elimination rate constants (K) were estimated from the slopes of the first linear declines in serum drug concentration-time profiles and the half-life (t1/2) calculated as 0.693/K.
↵2-c The areas under curves (AUC) were estimated using the trapezoidal method and the apparent clearance (CLip) calculated as dose/AUC.