Decrease in colony-forming activity of CFU-GM isolated from bone marrow of rats orally given FT and SRV 1-a
| Drug | No. of Colonies of CFU-GM/105Mononuclear Cells/Dish ± SD | ||
|---|---|---|---|
| Day 1 | Day 2 | Day 4 | |
| Control | 114.3 ± 9.2 (100)1-b | 118.6 ± 1.0 (100) | 126.4 ± 3.5 (100) |
| FT | 114.6 ± 4.8 (100) | 112.0 ± 12.0 (94.4) | 120.5 ± 13.4 (95.3) |
| SRV | 113.3 ± 4.5 (99.1) | 114.3 ± 6.1 (96.4) | 122.7 ± 8.2 (97.0) |
| FT and SRV | 91.8 ± 6.5 (80.3)* | 2.9 ± 2.4 (2.4)** | 0.3 ± 0.3 (0.2)** |
↵1-a Cells were collected at the 24th hr on days 1, 2, and 4 from bone marrow of rats orally administered FT alone or FT and SRV once daily for 4 days and cultured for 7 days under the conditions mentioned in Methods for counting CFU-GM colonies. Daily doses of FT and SRV were 60 and 30 mg/kg, respectively.
↵1-b Numerals in parentheses represent % of CFU-GM colonies from control rats.
Significantly different from mean values of control rats; * p < 0.05, ** p < 0.01.