Pharmacokinetic parameters of l-738,167 in blood
| Dose | N | CLB | Vdss,B | t½ |
|---|---|---|---|---|
| μg/kg | ml/hr/kg | liter/kg | hr | |
| 1 | 3 | 1.13 ± 0.2 | 0.18 ± 0 | 112 ± 8 |
| 3 | 3 | 1.11 ± 0.02 | 0.15 ± 0.01 | 98 ± 7 |
| 25 | 4 | 6.25 ± 1.5 | 0.82 ± 0.1 | 98 ± 25 |
| 250 | 4 | 40.5 ± 3.5 | 5.17 ± 0.7 | 92 ± 14 |
Results are means ± SD obtained after intravenous administration of [3H]l-738,167 to dogs