Prodrug | Parameter | PMEA | 2-Adenyl Acetic Acid | Mono-ester |
---|---|---|---|---|
Bis-POM PMEA | AUC (0–∞) (μg·hr/ml) | 2.95 | ND | ND |
Cmax(μg/ml) | 0.45 | ND | ND | |
Tmax (hr) | 1.0 | ND | ND | |
Percent of IV PMEA AUC | 38.2 | 0 | 0 | |
Bis-(phenyl)PMEA | AUC (0–∞) (μg·hr/ml) | 0.19 | 1.18 | 0.16 |
Cmax(μg/ml) | 0.18 | 0.63 | 0.23 | |
Tmax(hr) | 0.25 | 0.5 | 0.25 | |
Percent of IV PMEA AUC | 2.46 | 15.3 | 2.07 | |
Bis-(o-ethoxyphenyl) PMEA | AUC (0–∞) (μg·hr/ml) | 3.1 | 0.15 | 0.30 |
Cmax (μg/ml) | 0.39 | 0.12 | 0.23 | |
Tmax (hr) | 1.0 | 1.0 | 0.25 | |
Percent of IV PMEA AUC | 40.1 | 1.94 | 3.88 |
Cmax, maximum concentration; Tmax, time to maximum concentration; ND, not detected.