Moment analysis for biliary excretion of metabolites after instantaneous injection of semotiadil (R-enantiomer) and levosemotiadil (S-enantiomer) into perfused rat liver
| M-3 | M-4 | M-5 | M-7 | Total | |
|---|---|---|---|---|---|
| Semotiadil | (N = 3) | (N = 3) | (N = 2) | (N = 3) | |
| Ae (% of dose) | 5.36 ± 0.40 | 8.84 ± 0.56 | 1.25 ± 0.19 | 1.12 ± 0.60 | 16.1 ± 1.2 |
| Ae /(1 − FH ) (%) | 5.46 ± 0.40 | 9.01 ± 0.57 | 1.27 ± 0.20 | 1.14 ± 0.61 | 16.5 ± 1.2 |
| MRTe (min) | 17.3 ± 1.4 | 19.9 ± 2.5 | 28.1 ± 6.8 | 13.1 ± 1.0 | 19.1 ± 2.2 |
| Levosemotiadil | (N = 4) | (N = 4) | (N = 4) | (N = 4) | |
| Ae (% of dose) | 4.32 ± 1.76 | 4.66 ± 0.692-a | 0.90 ± 0.20 | 0.32 ± 0.032-a | 10.2 ± 1.52-a |
| Ae /(1 − FH ) (%) | 4.75 ± 1.94 | 5.12 ± 0.752-a | 0.99 ± 0.21 | 0.35 ± 0.042-a | 11.2 ± 1.62-a |
| MRTe (min) | 16.5 ± 1.1 | 13.3 ± 0.62-a | 13.9 ± 1.32-a | 9.16 ± 0.172-a | 14.8 ± 1.12-a |
Unchanged drugs were not detected.
↵2-a Significantly different between R- and S-metabolites at the 5% level of ANOVA.